The Financial Crimes Enforcement Network, on behalf of the U.S. Department of the Treasury, published a Request for Comment mandated by the GENIUS Act on innovative methods that regulated financial institutions use or could use to detect illicit activity involving digital assets. The request seeks input on approaches including application programming interfaces, artificial intelligence, digital identity verification, and the use of blockchain technology and monitoring. Treasury plans to use the comments to inform research on these tools’ effectiveness and costs, as well as related privacy and cybersecurity risks and other considerations, in the context of Executive Order 14178 on strengthening U.S. leadership in digital financial technology.